In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 771-81-3, name is 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid, the common compound, a new synthetic route is introduced below. 771-81-3
To a solution of 4-amino-2-methylmercaptopyrimidine-5-carboxylic acid (185 mg, 1 mmol) and p-methoxybenzyl amine (164 mg, 1.2 mmol) in N,N-dimethylformamide was added 1-hydroxybenzotriazole (92 mg, 92 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarboiimide hydrochloride (229 mg, 1.2 mmol). The reaction mixture was stirred at room temperature over night. The solvent was removed under reduce pressure. The residue was dissolved in ethyl acetate (30 mL) and washed by water (30 mL) and brine (30 mL), dried over sodium sulfate, and the solvent was ecaporated. The residue was purified by column chromatography (hexanes:ethyl acetate=1:1) to give the desired product as a white powder (245 mg, 81%). [0310] HPLC (4 minute gradient) tR=2.09 min; MS m/z 305.08 (M+H)+
Statistics shows that 771-81-3 is playing an increasingly important role. we look forward to future research findings about 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid.
Reference:
Patent; Lang, Hengyuan; Lan, Jiong; Fang, Yunfeng; US2005/20590; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia