In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7752-72-9, name is 5-Chloro-6-methylpyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Product Details of 7752-72-9
2) Preparation of 4,5-dichloro-6-methylpyrimidineThe 14.5g (0.1mol) 4-hydroxy-5-chloro-6-methylpyrimidine dissolved in 50ml of toluene, was added dropwise with stirring to the reaction flask 50ml of phosphorus oxychloride dropwise at reflux temperature the reaction completion 5-7 hours after, TLC monitored the reaction is complete. The toluene was evaporated under reduced pressure and an excess of phosphorus oxychloride, while stirring the reaction was poured into ice water, the aqueous phase was extracted with (3 ¡Á 50ml) and extracted with ethyl acetate, the combined organic phase was dried over anhydrous magnesium sulfate, filtered, desolvation . The residue was purified by column chromatography (eluent, ethyl acetate and petroleum ether (boiling range 60-90 ), the volume ratio of 1: 4) was isolated as a yellow liquid 14.43g, yield 88.5%.
The synthetic route of 7752-72-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenyang SinochemAgrochemicals R&D Co., Ltd.; Liu, Zhangling; Xu, Ying; Wang, Junfeng; Sun, Xufeng; Ban, Lanfeng; Xie, Yong; Li, Zhinian; Sun, Geng; (59 pag.)CN105348298; (2016); A;,
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