Analyzing the synthesis route of 7752-82-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7752-82-1, 5-Bromopyrimidin-2-amine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7752-82-1, name is 5-Bromopyrimidin-2-amine. A new synthetic method of this compound is introduced below., 7752-82-1

To a stirred solution of 5-bromopyrimidin-2-amine(A39, 1.0 g, 5.74 mmol) in DMF (20 mL) was added ethyl 3-bromo pyruvate(A15, 0.86 mL, 6.89 mmol) . The reaction mixture was Stirred for 16 h at Room temp and then concentrated under reduced pressure. The crude product was triturated with water and washed with n-pentane and dried to afford ethyl 6-bromoimidazo[l,2-a]pyrimidine-2-carboxylate A40 as light brown solid Yield: 1.50 g,(87%). LC-MS m/z : 268.20[M-H]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7752-82-1, 5-Bromopyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; JUBILANT BIOSYS LIMITED; VADIVELU, Saravanan; RAJAGOPAL, Sridharan; BURRI, Raghunadha Reddy; GARAPATY, Shivani; SIVANANDHAN, Dhanalakshmi; THAKUR, Manish Kumar; NATARAJAN, Tamizharasan; SWAMY, Indu N; NAGARAJU, Nagendra; KANAGARAJ, Subramaniam; MOHD, Zainuddin; SARKAR, Sayantani; SAMANTA, Swapan Kumar; ., Hariprakash; (284 pag.)WO2019/102494; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia