Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 83942-10-3, name is 4,5-Dichloro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4,5-Dichloro-6-methylpyrimidine
PREPARATIVE EXAMPLE 4 5-chloro-6-methyl-4-[N-methyl-2-(2-methyl-4-n-propylphenoxy)ethylamino]pyrimidine (compound number 166) To a solution of 3.2 g (0.02 mol) of 4,5-dichloro-6-methylpyrimidine were added 2.0 g (0.02 mol) of triethylamine and 4.7 g (0.02 mol) of N-methyl-2-(2-methyl-4-n-propylphenoxy)ethylamine, and the mixture was melt-reacted by heating it for 5 minutes on a heater. Upon completion of the reaction, 100 ml of benzene were added to the reaction mixture, and insoluble matters were filtered off. The filtrate was washed with water, dried over anhydrous sodium sulphate, and the benzene distilled off under reduced pressure, leaving an oil. The oil was isolated by column chromatography (Wakogel C-200, eluted with a 3:1 by volume mixture of benzene and ethyl acetate) to give 6.1 g of the desired product in the form of a pale yellow oil nD23.8 1.5632
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Reference:
Patent; Sankyo Company, Limited; Ube Industries, Limited; US4435402; (1984); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia