As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 893755-98-1, name is 1-(Pyrimidin-2-yl)piperidin-4-ol, molecular formula is C9H13N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 1-(Pyrimidin-2-yl)piperidin-4-ol
Step 2: 1-(1,4,5,6-Tetrahydro-2-pyrimidinyl)-4-piperidinol (181) Compound 180 (300 mg, 1.67 mmol) was combined with 10% palladium on carbon(Degussa type) (100 mg, cat.) and concentrated hydrochloric acid (500 mul_) into 10 ml. of acetic acid. The mixture was subjected to hydrogenation for 18 h at room temperature. The reaction mixture was then filtered and the solvent was removed under reduced pressure to give 304 mg (84%) of the desired compound lambdaZlambda_. 1H NMR (400 MHz, DMSOd6): delta 8.25 (m, 2 H), 4.03 – 3.41 (m, 3 H), 2.95 – 2.86 (m, 4 H), 2.09 – 1.55 (m, 6 H), 1.55 – 1.18 (m, 2 H).
With the rapid development of chemical substances, we look forward to future research findings about 893755-98-1.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/8895; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia