Electric Literature of 89487-99-0 , The common heterocyclic compound, 89487-99-0, name is 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile, molecular formula is C6H5N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a cooled solution of 4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile (8) (10.8 g, 65 mmol) in toluene (150 ml), phosphorus oxychloride (23.8 ml, 260 mmol) was slowly added. The reaction mixture was stirred at 110 C for 6 h. After evaporation of the organic solvent, the residue was cooled to room temperature and added a lot of ice water. At this time, a brown solid was formed and collected by filtration. The crude product was dried in a vacuum oven to give 4-chloro-2-(methylthio)pyrimidine -5-carbonitrile 9(6.8 g). This product was taken up for the next step without any purification. Yield: 58%; Purity: 90%; LC-MS m/z: 186.0 [M + H]+.
The synthetic route of 89487-99-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Ling-Ling; Li, Guo-Bo; Yan, Heng-Xiu; Sun, Qi-Zheng; Ma, Shuang; Ji, Pan; Wang, Ze-Rong; Feng, Shan; Zou, Jun; Yang, Sheng-Yong; European Journal of Medicinal Chemistry; vol. 56; (2012); p. 30 – 38;,
Pyrimidine | C4H4N2 – PubChem,
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