Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89792-07-4, name is 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., Formula: C7H7N3
2-methyl-7H-pyrrolo[2,3-d]pyrimidine (426 mg, 3.2 mmol) was dissolved in DMF (54 mL) cooled in an ice bath and treated with N-bromosuccinimide (569 mg, 3.2 mmol) portionwise under nitrogen. The resulting mixture was stirred for 20 minutes, allowed to warm to room temperature and stirred for 10 minutes. The reaction was quenched by the addition of CH3OH (5 mL) and the solvent removed under reduced pressure. The residue was purified by silica flash column chromatography using a heptane to ethyl acetate gradient. The desired fractions were collected and the solvent was removed under reduced pressure to afford 5-bromo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, 19.
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Reference:
Patent; Janssen Sciences Ireland UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; RABOISSON, Pierre Jean-Marie Bernard; EMBRECHTS, Werner Constant Johan; GUILLEMONT, Jerome Emile Georges; (42 pag.)US2017/253600; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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