The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Ethyl 2-chloropyrimidine-5-carboxylate
DIPEA (7.27 g, 56.3 mmol) was added drop wise to a stirred solution of ethyl 2- chloropyrimidine-5-carboxylate (3.50 g, 218.8 mmol) and 3-pyridinemethanamine (2.03 g, 18.8 mmol) in dry THF (30 ml_) and the reaction stirred at 60 ¡ãC for 16 hrs. The solvent was removed under reduced pressure and water (10 ml_) was added. The mixture was extracted with EtOAc (40 ml_ x3) and the combined organic extracts dried (Na2S04), filtered and concentrated in vacuo. The crude product was purified by column chromatography on silica gel eluting with Pet. EthenEtOAc (100:0 to 7:93) to afford the title compound as a brown solid, 3.50 g, 72percent. 1H NMR (400 MHz, CDCI3): delta 1 .38 (t, 3H), 4.36 (q, 2H), 4.74 (d, 2H), 6.03 (br s, 1 H), 7.29 (d, 1 H), 7.68 (d, 1 H), 8.55 (d, 1 H), 8.63 (d, 1 H), 8.85 (br s, 2H). LCMS m/z = 259 [M+H]+
With the rapid development of chemical substances, we look forward to future research findings about 89793-12-4.
Reference:
Patent; PFIZER INC.; CASIMIRO-GARCIA, Agustin; STROHBACH, Joseph Walter; HEPWORTH, David; LOVERING, Frank Eldridge; CHOI, Chulho; ALLAIS, Christophe Philippe; WRIGHT, Stephen Wayne; (213 pag.)WO2018/11681; (2018); A1;,
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