Analyzing the synthesis route of 933702-55-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 933702-55-7, 2-Chloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 933702-55-7 ,Some common heterocyclic compound, 933702-55-7, molecular formula is C5H3ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Dissolve 2-chloropyrimidine5-carhaldehyde (0.5 g, 3.5 mmol) in chloroform (10 mL), add diethyiaminosuifur trioxide (567 mg, 3,5 mmoi), then reflux for 1 hour. Cool the mixture to ambient temperature and quench with 1-120. Separate the layers, wash the organic fraction with 1-120 (2x), dry over Mg504, filter, collect the filtrate, and concentrate the filtrate under reduced pressure to provide the title product (327 mg, 51%),

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 933702-55-7, 2-Chloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; ESCRIBANO, Ana Maria; GONZALEZ, Maria Rosario; LAFUENTE BLANCO, Celia; MARTIN-ORTEGA FINGER, Maria Dolores; WILEY, Michael R.; (82 pag.)WO2016/187384; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia