Reference of 941685-26-3 ,Some common heterocyclic compound, 941685-26-3, molecular formula is C12H18ClN3OSi, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of intermediate 2 (3 g, 10.6 mmol), 1-butanol (30 mL)3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -1- (triisopropylsilyl) -1H-pyrrole (4.5 g, 12.7 mmol),Water (30 mL) and potassium carbonate (3.7 g, 26.5 mmol) was stirred at 100 & lt; 0 & gt; C.Then, tetrakis (triphenylphosphine) palladium (0) (0.7 g, 0.53 mmol) was added to the solution,The mixture was stirred at 100 & lt; 0 & gt; C overnight.After cooling to room temperature,The mixture was filtered through a bed of celite,Extraction under reduced pressure,Purification by silica gel column gave Intermediate 8 (2 g, 60%),As a yellow oil;
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,941685-26-3, its application will become more common.
Reference:
Patent; Hangzhou East China Pharmaceutical Group New Drug Institute Co., Ltd.; Yin Jianming; Lv Yubin; Li Bangliang; (18 pag.)CN106905322; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia