Reference of 947533-45-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947533-45-1, name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2, molecular weight is 176.97, as common compound, the synthetic route is as follows.
In a 40 mL vial, chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl- l,l ‘-biphenyl)[2-(2-aminoethyl)phenyl)]palladium(II) (0.025 g, 0.031 mmol), tert-butyl 3-((6-methoxy-2-(methylthio)-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyrimidin-4-yl)arnino)piperidine-l-carboxylate (0.15 g, 0.312 mmol), 2-bromo-5- fluoropyrimidine (0.083 g, 0.468 mmol) and CuCl (0.031 g, 0.312 mmol) were combined, then purged with argon. Then degassed DMF (3 mL) followed by CS2CO3 (0.407 g, 1.249 mmol) were added to the vial. The reaction was then heated at 100 C for 18 h. The mixture was cooled, diluted with ethyl acetate, washed with water, dried (Na2SC>4), filtered and the solvent was evaporated under reduced pressure. The material was purified by column chromatography on silica gel (0-100% EtOAc in hexanes) to afford the desired product. MS (m z) = 451 (M+H).
The chemical industry reduces the impact on the environment during synthesis 947533-45-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; SEGANISH, W. Michael; BRUMFIELD, Stephanie Nicole; LIM, Jongwon; MATASI, Julius, J.; MCELROY, William, T.; TULSHIAN, Dean, B.; LAVEY, Brian, J.; ALTMAN, Michael, D.; GIBEAU, Craig, R.; LAMPE, John William; METHOT, Joey; ZHU, Liang; WO2013/66729; (2013); A1;,
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