Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99979-77-8, name is 2-Chloro-5-methoxypyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-methoxypyrimidin-4-amine
Synthesis of 4-amino-2-chloropyrimidin-5-ol [0346] To a stirred solution of 2-chloro-5-methoxypyrimidin-4-amine (5 g, 31.44 mmol) in CH2CI2 (750 mL) under argon atmosphere at 0 °C was added BBr3 (45.5 mL, 471.69 mmol) drop-wise. The reaction was allowed to warm to RT and stirred for 32 h. After completion of the reaction (monitored by TLC), the reaction was quenched with methanol (22.5 mL) and stirred for lh. The suspension was filtered and the resultant solid dried in vacuo to afford 4-amino-2-chloropyrimidin-5-ol (4.5 g) as a brown solid and used without further purification. 1H-NMR (DMSO-< 5, 500 MHz): delta 10.04 (brs, 1H), 7.48 (s, 1H); LC- MS: 146.2 (M+l); (column; Eclipse XDB C-18 (150 4.6 mm, 5 mupiiota); RT 3.37 min. 0.05percent Aq TFA: ACN; 1.0 ml/min); TLC: 60percent EtOAc:hexanes (R/. 0.5).
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Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
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