The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate
Toluene (40.8g) was stirred and heated to 70C. DABCO (0.85g at 98%w/w, 0.007mols) and 2-cyanophenol (9.9g at 97.5%w/w, 0.08mols) were added at 10 minute intervals. After a further 10 minutes DBU (13.8g at 98%w/w, 0.09mols) was added over 5 minutes (exotherm to 74C). After stirring for a further 10 minutes, methyl (E)-2-{2-[6-chloropyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (24.2g at 98%w/w, 0.074mols) was added and the reaction stirred at 7O0C for 60 minutes (reaction was complete in 30 minutes). Hot water (750C) (78.3g) was added and the mixture stirred for 15 minutes at 70-750C, then settled and the aqueous phase separated. A second water wash (78.3g) was applied in the same way. The toluene phase (73,Ig) contained methyl (i^-2-{2-[6-(2-cyanophenoxy)pyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (38.6%w/w), 94.7% of theory.
With the rapid development of chemical substances, we look forward to future research findings about 131860-97-4.
Reference:
Patent; SYNGENTA LIMITED; WO2008/43978; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia