Synthetic Route of 89793-12-4 , The common heterocyclic compound, 89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of Intermediate 4: Compound 2 (620 g, 1.0 equiv) and DIPEA (1080 g, 2.2 equiv. were dissolved in NMP (3100 ml) and stirred for 20 min. Compound 3 (680 g, 1.02 equiv.) was added and the reaction mixture was heated to about 85-95 °C for 4 hrs. The solution was allowed to slowly cool to r.t. This solution was poured onto H20 (20 L) and much of the solid was precipitated out from the solution with strong stirring. The mixture was filtered and the cake was dried under reduced pressure at 50 °C for 24 hr., yielding 896 g of compound 4 (solid, 86.8percent).
The synthetic route of 89793-12-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; VIB VZW; KATHOLIEKE UNVERSITEIT LEUVEN; LIFE SCIENCES RESEARCH PARTNERS VZW; JARPE, Matthew, Blaire; BENOY, Veronick; HELLEPUTTE, Lawrence, Van; VAN DEN BOSCH, Ludo; (50 pag.)WO2016/90230; (2016); A1;,
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