Analyzing the synthesis route of Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

The synthetic route of 148550-51-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 148550-51-0, Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate, blongs to pyrimidines compound. Application In Synthesis of Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

To a solution of intermediate B (150mg, 0.76mmol) in MeCN (0.7ml) was added K2CO3. To this, a solution of intermediate A (174mg, 0.76mmol) in MeCN (0.7ml) was added dropwise resulting in a white suspension. Stirring at r.t. was continued for 30 EPO min after which the white suspension turned pale yellow. The reaction mixture was evaporated, re dissolved in EtOAc (10ml) and washed with water (5ml). The EtOAc layer was dried (Na2SO4) filtered and concentrated to dryness. Purification by flash chromatography (100percent DCM to 2percent MeOH/DCM) gave the title compound as an off- white solid (0.15g, 57percent). LCMS purity 89percent, m/z 349 [M+H]+.

The synthetic route of 148550-51-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHROMA THERAPEUTICS LTD; WO2006/123121; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia