Analyzing the synthesis route of Formula: C5H3Cl2FN2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,954220-98-5, 2,4-Dichloro-5-fluoro-6-methylpyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.954220-98-5, name is 2,4-Dichloro-5-fluoro-6-methylpyrimidine, molecular formula is C5H3Cl2FN2, molecular weight is 181, as common compound, the synthetic route is as follows.Formula: C5H3Cl2FN2

Preparation of compound 8: compound 6 (0.62 g, 3.43 mmol), 7 (0.67 g, 3.43 mmol 1) and triethylamine (1.14 g, 13.02 mmol) were dissolved in a mixed solvent of 15 mL of tetrahydrofuran and 0.8 mL of ethanol, and heated under reflux for 5 hours.After the reaction is finished, spin dry,The crude product was subjected to column chromatography to give 0.46 g of Compound 8. Yield: 32.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,954220-98-5, 2,4-Dichloro-5-fluoro-6-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Yinxingshu Pharmaceutical (Suzhou) Co., Ltd.; Chen Li; Shao Qing; Jiang Tao; Wu Jin; (20 pag.)CN109384783; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia