Adding a certain compound to certain chemical reactions, such as: 147118-37-4, N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide, blongs to pyrimidines compound. Application In Synthesis of N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
Method 2 Solution of aldehyde A (16 mg, 0.046 mmol) and ylide (R)-B (same as with method 1) (30 mg, 0.046 mmol) in 1 ml of toluene was reflux during 48h and evaporated under residue pressure to remove toluene. Product was purified by column chromatography (silica, EtOAc, Rf = 0.92) affording 10 18 mg (52%) as colorless viscous oil. 1H-NMR (300 MHz1 CDCI3): delta = 1.00 (s, 9H1 Me3C)1 1.26 (m, 3H + 6H, Me2CH + CH2Me), 3.52 (s, 3H, Me-N), 3.59 (s, 3H, MeSO2N)1 2.49 (m, 2H, CH2CO2Et), 2.69 (dd, 1 H, J = 15.75 Hz, J = 5.53 Hz, C(O)CHH), 2.83 (dd, 1 H, J = 15.75 Hz, J = 7.48 Hz, C(O)CHH), 3.25 (m, 1 H, Me2CH), 4.05 (q, J = 7.11 Hz, CH2Me), 4.59 (m, 1 H, CH), 5.95 (d, 1H, J = 16.50 Hz, CH=CH), 7.07 (m, 2H, Ar), 7.36 (m, 7H, CH, CH=CH + Ar), 7.55 (m, 2H, CH, Ar), 7.65 (m, 4H, CH, Ar).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-37-4, N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide, and friends who are interested can also refer to it.
Reference:
Patent; RATIOPHARM GMBH; WO2009/24323; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia