The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149765-15-1, name is N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide. This compound has unique chemical properties. The synthetic route is as follows. name: N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
A solution of DIAD (0.24 mL, 1.20 mmol) in anhydrous THF (1 mL) was added dropwise to amixture of 34 (180 mg, 0.74 mmol), 4a (150 mg, 0.61 mmol), and Ph3P (300 mg, 1.20 mmol)in anhydrousTHF (10 mL) at room temperature. The reaction mixture was stirred for 24 h, andit was then concentrated under reduced pressure. The crude residue was purified by columnchromatography on silica gel (gradient DCM/MeOH, 60:1, v/v; 40:1, v/v; 30:1, v/v) to give 36a(220 mg, 78%) as a colorless oil. 1H NMR (300 MHz, 0D013): 68.16 (s, 1H, NHCO), 7.29(dd,J= 0.9 Hz, 1H, H-6), 6.53 (dd, J= 3.6, 0.9 Hz, 1H, H-6), 4.74-4.31 (m, 4H, H-31 ,H-i ), 4.18-3.86 (m, 7H, H-2?, 2 x 0H20H3, PCH2), 1.36-i .27 (m, 15H, (0H3)30, 2 x 0H20H3); 130 NMR(150 MHz, 0D013): 6175.7 (NHCO), 152.3 (0-4, C-7a), 151.6 (0-2), 130.1 (0-6), 114.2 (C-4a),100.1 (0-5), 82.9 (d, 1Jc,p = 173.2 Hz, C-3 ), 79.4 (dd, 2JC,F = 19.1 Hz, 3Jc,p = 10.9 Hz, C-2 ),64.9 (d, 1Jc,p = 166.9 Hz, CH2P), 62.7, 62.6 (CH2CH3), 44.9 (d, 3JC,F = 8.5 Hz, C-i ), 40.5(C(0H3)3), 27.7 (C(CH3)3), 16.7, 16.6 (CH2CH3); 31P NMR (121 MHz, 0D013): 620.9; HRMS for019H2901FN405P [M+H] calcd.: 479.1621, found: 479.1617.
With the rapid development of chemical substances, we look forward to future research findings about 149765-15-1.
Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; ANDREI, Graciela; DE JONGHE, Steven; GROAZ, Elisabetta; HERDEWIJN, Piet; LUO, Min; SCHOLS, Dominique; SNOECK, Robert; (81 pag.)WO2018/55071; (2018); A1;,
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