Related Products of 1421372-94-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1421372-94-2, name is N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.
N-(4-fluoro-2-methoxy-5-nitro-phenyl)-4-(1-methylindol-3-yl)pyrimidin-2-amine (1300 mg, 3.3 mmol) dissolved in DMA (10 ml) and N-(4-fluoro-2-methoxy-5-nitro-phenyl)-4-(1- methylindol-3-yl)pyrimidin-2-amine (1.07 ml, 9.91 mmol) added followed by TEA (0.92 ml, 6.61 mmol) and the reaction heated to 140C for 30 minutes under microwave conditions and quenched with water (20 ml). The reaction mixture was extracted with ethyl acetate (3 x 20 ml). The combined organics were washed with water, dried over MgSO4 and concentrated in vacuo to a red solid. Used in subsequent steps with no further purification.
According to the analysis of related databases, 1421372-94-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARVINAS, INC.; YALE UNIVERSITY; GREW, Andrew, P.; ZIMMERMANN, Kurt; WANG, Jing; BERLIN, Michael; DONG, Hanqing; ISHCHENKO, Alexey; QIAN, Yimin; CREWS, Craig, M.; JAIME-FIGUEROA, Saul; BURSLEM, George; (855 pag.)WO2018/119441; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia