Synthetic Route of 2244-11-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds.5.1.2.12 5-[3-(Biphen-4-yl)-2-oxopropyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (19) 27% Yield, mp 173-5 C (decomp. 150 C). 1H NMR (acetone-d6) delta 10.24 (s, 2H, NH), 7.60-7.67 (m, 2H), 7.43-7.54 (m, 3H), 7.30-7.37 (m, 3H), 7.16-7.19 (m, 1H), 5.80 (s, 1H, OH), 3.30 (s, 2H), 2.14 (s, 2H). Anal. % (C19H16N2O5) calculated: C 64.77, H 4.58, N 7.95; found C 64.47, H 4.27, N 7.67.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.
Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia