Synthetic Route of 4595-61-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4595-61-3, name is Pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below.
5-pyrimidinecarboxylic acid 1.000 mmol was weighed at 2 ° CAnd 2-(7-oxobenzotriazole)-N,N,N’,N’-tetramethyluron hexafluorophosphate(HATU) 1.000 mmol was placed in a round bottom flask,Dissolved with 8mLDCM,After stirring for 10 min, N,N-diisopropylethylamine (DIPEA) was added 1.700 mmol.Stirring was continued for 10 min, and a solution of 5-methyl-7-(2-fluoro-4-aminophenoxy)-pyrazolo[1,5-a]pyrimidine 0.800 mmol in DCM was slowly added dropwise. After 10 min, the system was placed. Reaction at 35 ° C for 24 h,TLC detection;After the reaction is completed, the organic phase is washed three times with a saturated sodium chloride solution, and the reaction by-products are washed away.The organic phase was dried over anhydrous sodium sulfate and filtered to give a crude material.Pass through the column [V: V (ethyl acetate: petroleum ether) = 1:6],Get a white solid0.060g,That is, the product 7-[2-fluoro-4-(5-pyrimidinamide)phenoxy]-5-methylpyrazolo[1,5-a]pyrimidine(1H NMR and 13C NMR spectra are shown in Figure 7),The yield was about 42percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4595-61-3, its application will become more common.
Reference:
Patent; Guangzhou Medical University; Zhang Chao; Liang Xintong; Xie Guoquan; Luo Guolin; Wu Wenhao; Yu Lihong; (25 pag.)CN108727386; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia