Adding a certain compound to certain chemical reactions, such as: 60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-Amino-6-chloropyrimidine-5-carbonitrile, blongs to pyrimidines compound. Recommanded Product: 4-Amino-6-chloropyrimidine-5-carbonitrile
24.89 kg of tetrahydrofuran was added to a 100 L reaction kettle, and stirring was started, followed by the addition of 2.84 kg of (S)-3-(1-aminoethyl)-8-chloro-2-phenylquinolin-4(1H)-one and 1.34. Kg 4-amino-5-cyano-6-chloropyrimidine, heated to 65 ¡À 5 C, then add 4.22 kg of cesium carbonate, continue to reflux for 1 to 1.5 hours, HPLC to monitor the reaction to the end; 7.10 kg of acetone was washed, the solvent was removed from the filtrate, and 20 kg of purified water was added thereto for stirring for 1 to 2 hours, and the mixture was centrifuged, and purified water was washed twice. The obtained solid was air-dried at 70 ¡À 5 C for 10 hours or more to obtain 3.55 kg of the title compound.3.55 kg of the above crude product was added to 43.34 kg of acetone at room temperature, stirred until it was dissolved, filtered, and the filtrate was added to a 100 L reaction vessel, heated to reflux, and some acetone was distilled off until the residue in the kettle was slightly turbid, and the mixture was slowly added dropwise. Kg of methanol, after the completion of the addition, naturally reduce to room temperature, then cool to 5 ¡À 5 C, heat crystallization for more than 1 hour, filtration, filter cake with a mixture of 0.78 kg weight ratio of acetone / methanol = 1/2, the resulting The solid was vacuum dried at 60 ¡À 5 C for more than 12 hours to obtain 2.23 kg of (S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-di) Hydroquinolin-3-yl)ethyl)amino)pyrimidine-5-cyano, yield 62.0%.
The synthetic route of 60025-09-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Zhao Liwen; Sha Xiangyang; Ye Shichun; Ding Zhaobing; Chen Cheng; Li Linyi; (19 pag.)CN109516975; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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