Analyzing the synthesis route of Safety of Pyrimidine-5-carboxylic acid

With the rapid development of chemical substances, we look forward to future research findings about 4595-61-3.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4595-61-3, name is Pyrimidine-5-carboxylic acid, molecular formula is C5H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Pyrimidine-5-carboxylic acid

Example 1.32: Preparation of (tf)-(5-(4-(2-(2-Methylpyrrolidin-l- yl)ethyl)phenyl)isoindolin-2-yl)(pyrimidin-5-yl)methanone (Compound 29).In a 10 mL microwave vial were placed (R)-5-(4-(2-(2-methylpyrrolidin-l- yl)ethyl)phenyl)isoindoline (0.100 g, 0.326 mmol), pyrimidine-5-carboxylic acid (0.0607 g, 0.489 mmol), triethylamine (0.0910 mL, 0.653 mmol), PS-carbodiimide (1.02 g, 1.63 mmol), and CH2Cl2 (3 mL). The reaction was heated under microwave irradiation at 1200C for 1 h. The mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by HPLC to give the TFA salt of the title compound as a white solid (0.060 mg). LCMS m/z = 413.2 [M+H]+; 1H NMR (400 MHz, Methanol-*/,) delta ppm 1.26-1.31 (m, 3H), 1.48 (dd, J = 6.44, 3.66 Hz, 4H), 2.10 (s, 2H), 3.03-3.18 (m, 2H), 3.44-3.58 (m, IH), 3.69-3.80 (fn, IH), 4.91-4.96 (m, IH), 4.96-5.00 (m, IH), 5.01-5.08 (m, 2H), 7.34-7.50 (m, 4H), 7.54-7.67 (m, 4H), 9.10 (s, 2H), 9.30 (s, IH).

With the rapid development of chemical substances, we look forward to future research findings about 4595-61-3.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2009/105206; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia