Synthetic Route of 2227-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
Example 17.4: (3f?,4S)-4-Butyl-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine (20, R = Et); Formaldehyde (86 mul_, 1.1 mmol, 37 wt% solution in water) followed by 9-deazaadenine (112 mg, 0.84 mmol) are added to a solution of 19 (R = Et) (100 mg, 0.56 mmol) in 1 ,4-dioxane (1 mL) and water (2 ml_). The reaction mixture is warmed to 85 0C and after 1 h the crude reaction mixture absorbed onto silica and eluted down a silica column using a gradient 5 – 30% (7 N NH3 in MeOH) in CH2CI2. The crude product is collected, concentrated and subjected to flash chromatography (5 : 4.5 : 0.5, CH2CI2 : MeOH : 28% aq. NH4OH) to afford 20 (R = Et) as an off- white solid (90 mg, 56%). 1H NMR (500 MHz, CD3OD): delta = 8.17 (s, 1H), 7.49 (s, 1H), 3.86 – 3.83 (m, 1 H), 3.81 (q, J = 13.2 Hz, 2H), 3.05 (dd, J = 9.6, 8.0 Hz, 1H), 2.74 (dd, J = 10.4, 6.3 Hz, 1 H), 2.69 (dd, J = 10.4, 4.0 Hz, 1H), 2.17 (dd, J = 9.7, 8.0 Hz. 1H), 1.98 – 1.90 (m, 1H), 1.57 – 1.47 (m, 1H), 1.34 – 1.24 (m, 5H) and 0.89 ppm (t, J = 6.9 Hz, 3H). 13C NMR (125 MHz, CD3OD): delta = 152.1 , 151.0, 147.0, 130.1 , 115.1, 112.6, 77.8, 62.4, 59.7, 49.1 , 48.6, 34.0, 31.5, 23.8 and 14.4 ppm. ESI-HRMS for C15H24N5O [MH]+ calcd, 290.1981; found, 290.1988
According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALBERT EINSTEIN COLLEGE OF YESHIVA UNIVERSITY; INDUSTRIAL RESEARCH LIMITED; EVANS, Gary Brian; LONGSHAW, Alistair Ian; SCHRAMM, Vern L.; TYLER, Peter, Charles; WO2011/8110; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia