Anderson, Neal G.; Ary, Thomas D.; Berg, James L.; Bernot, Peter J.; Chan, Yeung Y.; Chen, Chien-Kuang; Davies, Merrill L.; DiMarco, John D.; Dennis, Ronald D.; Deshpande, Rajan P.; Do, Hoang D.; Droghini, Roberto; Early, William A.; Gougoutas, Jack Z.; Grosso, John A.; Harris, John C.; Haas, Oscar W.; Jass, Paul A.; Kim, Daniel H.; Kodersha, Gus A.; Kotnis, Atul S.; LaJeunesse, Jean; Lust, David A.; Madding, Gary D.; Modi, Sandeep P.; Moniot, Jerome L.; Nguyen, Andrew; Palaniswamy, Venkatapuram; Phillipson, Douglas W.; Simpson, James H.; Thoraval, Dominique; Thurston, David A.; Tse, Kai; Polomski, Robert E. published the artcile< Process Development of 5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl]propyl]-1H-indole Dihydrochloride>, SDS of cas: 5018-38-2, the main research area is fluoromethoxy pyrimidinyl piperazinylpropyl indole dihydrochloride synthesis; antidepressant fluoromethoxypyrimidinyl piperazinylpropyl indole dihydrochloride preparation.
5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indole dihydrochloride (1) facilitates 5-HT neurotransmission and was an antidepressant drug candidate. The development of a safe, rugged process for the large-scale, chromatog.-free preparation of this compound is described. The main areas of optimization included a Fischer indole synthesis, preparation and chlorination of a monohydroxypyrimidine, and coupling of the resultant fragments to prepare the drug substance.
Organic Process Research & Development published new progress about Antidepressants. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, SDS of cas: 5018-38-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia