With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, molecular weight is 142.1127, as common compound, the synthetic route is as follows.Recommanded Product: 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione
General procedure: 4.4.4. Method D (Na2CO3/DMF)Preparation of N-{[(4-hydroxy-3-nitrophenyl)carbamoyl]amino}-2,4,6-trioxo-1,3-diazinane-5-carboxamide (109). A mixtureof sodium bicarbonate (130 mg; 1.2 mmol), N,N-dimethylformamide(3 ml) and barbituric acid (256 mg 2.2 mmol) wassonicated for 1 h at 60 C. Into this solution the desired phenyl carbamate109bCF (603 mg; 2.2 mmol) was added. The reaction mixturewas sonicated at 100 C for 2 h followed by heating at 130 Cfor 2 additional hours. The reaction mixture was mixed with 5%hydrochloric acid (30 ml) and left to stir at room temperature for1 h. The formed precipitate was isolated via vacuum filtration,washed with water (3 30 ml), refluxed in ethanol (15 ml) for15 min, and then filtered to give the pure product (89%). 1H NMR(DMSO-d6, Agilent 400 MHz) d 11.15 (3H, br s), 10.59 (1H, s),9.42 (1H, br s), 9.30 (1H, s), 7.87 (1H, d, J = 8 Hz), 7.36 (1H, d,J = 4 Hz), and 7.08 (1H, d of d, J1 = 8 Hz, J2 = 4H) ppm. EMS (CH3-OH) m/z 365 (M1); M2 (366) m/z 366, 185 and 186.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, and friends who are interested can also refer to it.
Reference:
Article; Hron, Rebecca J.; Jursic, Branko S.; Neumann, Donna M.; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6183 – 6193;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia