Related Products of 10070-92-5 , The common heterocyclic compound, 10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of equimolar pyrimidine-5-carbaldehyde and 3-acetylindole in ethanol (50 mL) was refluxed for 3 h following up the drop by drop addition of 20% sodium hydroxide solution yielded(2E)-1-(1H-indol-3-yl)-3-(pyrimidine-5-yl)prop-2-en-1-one (1). On completion of the reaction, the product was achieved by pouring the reaction mixture on to the ice cooled water to yield the precipitate [53]. Yield 81%; yellow-colored crystals; m. p: 125-127 C; Anal. calc. for C15H11N3O:C 72.28%,H 4.45%, N 16.86%; found: C 72.32%, H 4.40%, N 16.91%;IR numax(cm-1): 1535 (C=N), 1610 (C=N), 1734 (C=O), 3190(NH), 2985 (CH-Ar); 1H NMR (CDCl3)delta(ppm): 7.083 (s, 1H,Ar-H), 7.142 (s, 1H, Ar-H), 7.310 (s, 1H, Ar-H), 7.371 (s,1H, Ar-H), 7.410-7.489 (d, 1H, -HC=CH-), 8.198-8.257(m, 4H, Ar-H), 8.294-8.310 (d, 1H, -HC=CH-), 10.805 (s,1H, NH); 13C NMR (CDCl3)deltappm: 121.41, 121.89, 122.33,123.10, 124.21, 124.93, 125.09, 125.48, 125.88, 126.22,126.95, 127.37, 131.47, 132.51, 174.29 (C=O); ESI-MS(m/z): [M++1] 250.25 (250.09).
The synthetic route of 10070-92-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Arshad, Mohammad; Journal of the Iranian Chemical Society; vol. 17; 6; (2020); p. 1305 – 1315;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia