Electric Literature of 1060815-90-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1060815-90-8, name is 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3ClIN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
-lodopropane (2.1 mL, 19.68 mmol) was added to a mixture of 2-chloro-5-iodo-7H- pyrrolo[2,3-d]pyrimidine (5.50 g, 19.8 mmol) and cesium carbonate (19.18 g, 59.04 mmol) in DMF (30 mL). The mixture was stirred at room temperature for 3 hours. The reaction mixture was diluted with EtOAc, washed with water, brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 10% EtOAc in hexane to afford the title compound as a white solid (5.5 g, 87%). 1H NMR (400 MHz, CDCl3): delta ppm 1.50 (d, 6H), 5.10 (m, 1 H), 7.36 (s, 1 H), 8.55 (s, 1 H). LCMS (System 10) Rt = 3.6 minutes MS m/z 322 [M+H]+
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060815-90-8, 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine.
Reference:
Patent; PFIZER LIMITED; ANDREWS, Mark, David; BAGAL, Sharanjeet, Kaur; BROWN, David, Graham; GIBSON, Karl, Richard; OMOTO, Kiyoyuki; RYCKMANS, Thomas; SABNIS, Yogesh; SKERRATT, Sarah, Elizabeth; STUPPLE, Paul, Anthony; WO2014/53967; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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