Adding a certain compound to certain chemical reactions, such as: 1439-08-3, 5-Bromo-4-(tert-butyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1439-08-3, blongs to pyrimidines compound. Product Details of 1439-08-3
To a stirred solution of commercially available 5-bromo-4-(tert-butyl)-pyrimidine (215 mg, 1 mmol) in THF (1 ml) and toluene (4 ml) was added triisopropyl borate (229 mg, 282 tl, 1.22 mmol) at -78 C followed by a drop-wise addition of n-butyl lithium (1 .6N in hexane) (731 tl, 1.17 mmol) at -78 C. The solution was allowed to stir at -78 C for 45 mm and then allowed to warm to room temperature. The reaction mixture was quenched by addition of 1M hydrochloride solution (2.5 ml) to pH = 1, diluted with water (5 ml) and extracted with diethyl acetate (2 x 40 ml). The combined organic layers were washec with brine (30 ml), dried (Mg504) and evaporated to yield (4-(tert-butyl)-pyrimidin-5-yl)-boronic acid (135 mg) as a light yellow oil, MS (ISP) mz = 181.1 [(M+H)i, which was used without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1439-08-3, 5-Bromo-4-(tert-butyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HOENER, Marius; WICHMANN, Juergen; (55 pag.)WO2017/72083; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia