Electric Literature of 150010-20-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 150010-20-1, name is 2-Bromo-5-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
A flask was charged with trans-4-(tert-butyldimethylsiloxy)- 1 -buten- 1 -ylboronic acid pinacol ester (3.37 mL, 9.61 mmol), cesium carbonate (6.89 g, 21.13 mmol), triphenyiphosphine (1.01 g, 3.84 mmol), 2- bromo-5-methylpyrimidine (1.70 g, 9.80 mmol), ACN (60 mL), and water (15 mL). Argon was bubbled through the reaction mixture. Diacetoxypalladium (0.2 16 g, 0.96 mmol) was then added and Argon was bubbled through the reaction again. The mixture was then heated at 85 C for 16 h. Water was added to the mixture which was then extracted with EtOAc. The EtOAc layer was dried, concentrated, and purified by silica gel column chromatography with gradient hexanes/EtOAc solvent system to give (E)-2- (4-((tert-butyldimethylsilyl)oxy)but- 1-en-i -yl)-5-methylpyrimidine (Example 70.1, 2.3 g 86%) as a yellow oil. LCMS-ESI (pos.) m/z: 279.2 (M+H)t
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150010-20-1, 2-Bromo-5-methylpyrimidine.
Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
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