Reference of 16097-60-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below.
Example 8 N4-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)phenyl]-6-(trifluoromethyl)pyrimidine-2,4-diamine 32 mg (0.11 mmol) of 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)aniline and 26 mg (0.12 mmol) of 4-chloro-6-(trifluoromethyl)pyrimidine-2-amine are suspended in 5 ml of water and 0.07 ml of 2N hydrochloric acid. The reaction mixture is heated at reflux for 20 hours. After cooling, the mixture is made alkaline using dilute aqueous sodium hydroxide solution, a little methanol is added and the mixture is extracted with ethyl acetate. The extract is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC. Yield: 24 mg (55% of theory) LC-MS (Method 2): Rt=2.05 min. MS (ESI pos.): m/z=403 [M+H]+. 1H-NMR (DMSO-d6-, 400 MHz): S=4.18 (s, 2H), 6.33 (s, 1H), 6.51 (dd, 1H), 6.82 (d, 1H), 6.93 (br. s, 2H), 7.21-7.29 (m, 2H), 7.41 (dd, 1H), 7.89 (dd, 1H), 8.11 (d, 1H), 9.72 (s, 1H), 11.60 (br. s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16097-60-2, its application will become more common.
Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia