In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1780-40-1, name is 2,4,5,6-Tetrachloropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4Cl4N2
(4.408 mmol) of 4- (10H-phenoxazin-10-yl) phenylboronic acid were successively added,(0.92 mmol) of 2,4,5,6-tetrachloropyrimidine,103 mg (0.46 mmol) of palladium acetate,241 mg (0.92 mmol) of triphenylphosphine as well1.17 g (11.04 mmol) of anhydrous potassium carbonate was added100ml three-mouth flask,Then, 50 mL of ethylene glycol dimethyl ether was added as a reaction solvent,Air was removed and refluxed for 24 h.After completion of the reaction, the reaction solvent was distilled off under reduced pressure, and the mixture was extracted three times with DCM and then dried by passing through a column.To give 0.38 g of a yellow solid,Yield 38.6%.
The synthetic route of 1780-40-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dalian University of Technology; Liu, Di; Zhang, Dan; (16 pag.)CN106243086; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia