Electric Literature of 56-09-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below.
Phosphorus oxychloride (58.7mL, 630mmol) was added to a 500mL single-necked round bottom flask, N, N-dimethylformamide (12.1mL, 157mmol) was added dropwise at a low temperature bath of 5 C, and then transferred to 25 C , 2-Amino-4,6-dihydroxypyrimidine (10g, 78.7mmol) was added in portions, and the temperature was raised to 100 C to react for 5 hours. The reaction was stopped, most of the phosphorus oxychloride was removed by rotary evaporation under reduced pressure, water (900 mL) was added, and the mixture was stirred at 25 C for 32 hours, filtered, and the resulting solid was added to ethyl acetate (50 mL). After stirring for 30 minutes, Filter and dry the filter cake to give the title compound as a yellow solid (12.2 g, 80.8%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Shenzhen Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Zhong Wenhe; Deng Kang; (40 pag.)CN111072675; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia