Adding a certain compound to certain chemical reactions, such as: 10320-42-0, 2-Chloro-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10320-42-0, blongs to pyrimidines compound. HPLC of Formula: C4H2ClN3O2
tert-Butyl 4-( ( 1 S ,2R )-2-(2-aminoethyl )cyclopropyl )piperidine-1-carboxylate(Intermediate 7) (600 mg, 2.2 mmol), 2-chloro-5-nitropyrimidine (427 mg, 2.6 mmol), andpotassium carbonate (460 mg, 3.3 mmol) were stirred in DMF (5 mL) at rt for 12 hrs. The5 mixture was filtered, washing with EtOAc. The resulting organic layer was washed withsaturated aqueous ammonium chloride solution (10 mL x 1), dried over MgS04, filtered, andconcentrated under reduced pressure to afford the title compound (730 mg, 85percent) as a crudeproduct to be used for the next step. LC/MS (m/z): 392 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10320-42-0, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ACTON, John, J.; EDMONDSON, Scott, D.; LIU, Ping; MILLER, Michael, W.; WOOD, Harold, B.; DUBOIS, Byron, G.; GEISS, William, B.; WO2014/52379; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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