Reference of 38275-43-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38275-43-3, name is 2-(Methylthio)pyrimidine-5-carbonitrile, molecular formula is C6H5N3S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 2-(methylsulfanyl)pyrimidine-5-carbonitrile (25.00 g, 165.35 mmol, 1.00 eq) and hydroxylamine hydrochloride (22.98 g, 330.70 mmol, 2.00 eq) in ethanol (250.00 ml) and water (250.00 ml) was added sodium hydrogen carbonate (27.78 g, 330.70 mmol, 2.00 eq). The reaction was stirred at 70 C for 16 h. This mixture was filtered and washed with water (50 ml*4). The residue was collected and evaporated. This residue N’-hydroxy-2-(methylsulfanyl)pyrimidine-5- carboximidamide (29.00 g, crude) was used for next step without further purification
According to the analysis of related databases, 38275-43-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; BRUNET, Stephane; GOeRTZ, Andreas; GOURGUES, Mathieu; HILT, Emmanuelle; JAKOBI, Harald; NAUD, Sebastien; REBSTOCK, Anne-Sophie; DUCERF, Sophie; (78 pag.)WO2019/122323; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia