Application of 20737-41-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20737-41-1, name is 4-Aminopyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
(Step 1) Methyl 4-aminopyrimidine-5-carboxylate (0191) (0192) 4-Aminopyrimidine-5-carboxylic acid (10.0 g, 71.9 mmol) was dissolved in methanol (100 ml), the reaction solution was cooled to 0 C., then concentrated sulfuric acid (25 ml) was slowly added dropwise, and the resulting mixture was stirred at 85 C. for 12 hours. The reaction liquid was concentrated under reduced pressure, then the resulting solution was diluted with water, and sodium hydrogen carbonate (10.0 g) was added. The resulting mixture was extracted with ethyl acetate (80 ml¡Á4), the extracts were combined, washed with a saturated saline solution, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, the obtained residue was stirred in a mixed solvent (petroleum ether:ethyl acetate=8:1), and the precipitated solid was filtered and dried to obtain the title compound (9.90 g, 90%). (0193) 1H-NMR (400 MHz, DMSO-d6): delta 8.72 (s, 1H), 8.53 (s, 1H), 8.04 (s, 1H), 7.62 (s, 1H), 3.83 (s, 3H); MS (ESI) m/z 154 (M+H)+
According to the analysis of related databases, 20737-41-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ajinomoto Co., Inc.; UENO, Hirokazu; YAMAMOTO, Takashi; MIYAZAWA, Tomoko; SHINKAI, Kenji; ARISAKA, Harumi; TAKANOHASHI, Toshiyuki; (122 pag.)US2016/244451; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia