Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19646-07-2, name is 2,4-Dichloro-5-methoxypyrimidine. A new synthetic method of this compound is introduced below., Safety of 2,4-Dichloro-5-methoxypyrimidine
Production Example 1Synthesis of 2-methoxy-4-methylpyrimidin-5-ol (Prep 1-5)(1) 2-Chloro-5-methoxy-4-methylpyrimidine (Prep 1-1)2,4-Dichloro-5-methoxypyrimidine (10 g) was dissolved in THF (100 ml), and while cooling, iron(III) acetylacetone (1.97 g), methyl magnesium chloride (3.0 M: 22.4 ml) were then added to the solution. The obtained mixture was stirred at room temperature overnight. Thereafter, iron(III) acetylacetone (1.97 g), and methyl magnesium chloride (3.0 M: 22.4 ml) were added to the reaction solution further twice. Thereafter, a 1 N hydrochloric acid aqueous solution was added to the reaction mixture, and diethyl ether was then added to the reaction solution to carry out liquid separation and extraction. The organic layer was dried over magnesium sulfate, and the solvent was then concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-heptane:ethyl acetate), so as to obtain the title compound (6.6 g).1H-NMR (400 MHz, CDCl3) 5 (ppm): 2.46 (s, 3H), 3.92 (s, 3H), 8.06 (s, 1H).
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Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; US2012/95031; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia