Related Products of 63200-54-4 , The common heterocyclic compound, 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Into a 50 ml_ vial was placed 2,4-dichloro-5H-pyrrolo[3,2-c/]pyrimidine [CAS 63200-54-4] (1 g, 5.319 mmol), DMF (10 ml_), DIPEA (2.75 ml_, 16 mmol) and benzyl bromide (0.7 ml_, 5.85 mmol). The vial was sealed and shaken for 16 hours at room temperature. The solvents were removed under reduced pressure. The crude was purified via silica gel column chromatography using a heptane to ethyl acetate gradient. The best fractions were pooled and the solvents were removed under reduced pressure to afford B. LC-MS (M+H) m/z = 278
The synthetic route of 63200-54-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN R&D IRELAND; MC GOWAN, David Craig; LAST, Stefaan Julien; PIETERS, Serge Maria Aloysius; EMBRECHTS, Werner; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; WO2014/56953; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia