As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine, molecular formula is C7H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C7H3Cl2N3
A mixture of 2,4-dichloropyrido[3,2-d]pyrimidine (150 mg, 749.91 mupiiotaomicron, 1 eq), 4,5,6,7- tetrahydro-lH-indol-5-amine (113.48 mg, 749.91 muiotaetaomicron, 1 eq) and DIEA (387.68 mg, 3.00 mmol, 522.48 mu., 4 eq) in z-PrOH (10 mL) was stirred at 55 C for 2 h. The reaction mixture was concentrated to yield the residue which was purified on silica gel column chromatography (from PE/EtOAc = 3/1 to 1/1, TLC: PE/EtOAc = 1/1, Rf = 0.50) to yield 2-chloro-N-(4,5,6,7-tetrahydro- lH-indol-5-yl)pyrido[3,2-d]pyrimidin-4-amine (120 mg, 397.52 muiotaetaomicron, 53.0% yield, 99.3% purity) as a yellow solid. 1H MR (400 MHz, CDCb) S ppm 8.64 (dd, J= 1.5, 4.3 Hz, 1H), 8.01 (dd, J = 1.5, 8.5 Hz, 1H), 7.85 (s, 1H), 7.64 (dd, J= 4.3, 8.3 Hz, 1H), 7.44 (d, J= 8.5 Hz, 1H), 6.70 (t, J = 2.6 Hz, 1H), 6.04 (t, J= 2.6 Hz, 1H), 4.80-4.70 (m, 1H), 3.10 (dd, J= 5.3, 15.3 Hz, 1H), 2.99-2.45 (m, 3H), 2.24-2.08 (m, 2H); ES-LCMS m/z 300.1 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 39551-54-7.
Reference:
Patent; KYN THERAPEUTICS; CASTRO, Alfredo C.; EVANS, Catherine Anne; (632 pag.)WO2018/195397; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia