With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74356-36-8, name is 2,4-Dimethyl-pyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, molecular weight is 152.1506, as common compound, the synthetic route is as follows.Quality Control of 2,4-Dimethyl-pyrimidine-5-carboxylic acid
110 mg (0.72 mmol) of 2,4-dimethyl-pyrimidine-5-carboxylic acid and 215 mg (0.57 mmol) of O-(benzotriazol-1-yl)N,N,N’,N’-tetramethyluronium-hexa-fluorophosphate are dissolved in 4 mL of N,N-dimethylformamide and 62 muL (0.57 mmol) of 4-methyl-morpholine are added. The mixture is stirred for 10 min and a solution of 170 mg (0.47 mmol) [(R)-1-piperidin-4-yl-2-(2,4,5-trifluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester and 102 muL (0.57 mmol) of di-iso-propylethylamine in 4 mL of N,N-dimethylformamide is added. The reaction mixture is stirred for 2 h at room temperature, and diluted with ethyl acetate. The organic layer is washed with brine, saturated sodium bicarbonate solution and brine, dried with sodium sulfate, filtered and concentrated in vacuo to yield the title compound. LC/MS (I) (5-95%, 5 min): rt 3.89 min; m/z 437, 493 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,74356-36-8, 2,4-Dimethyl-pyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; BIOVITRUM AB; EP2019099; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia