Reference of 5750-76-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5750-76-5, name is 2,4,5-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2- (isopropylsulfonyl) aniline (1 g, 5 mmol)And 2,4,5-trichloropyrimidine (1.1 g, 6 mmol)Was dissolved in N, N-dimethylformamide (30 mL)Sodium hydride (60%, 0.4 g, 10 mmol) was added,25 C for 12 hours.(30 mL x 3), the organic phase was combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated in vacuo,The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 25: 1)The product (0.8 g, yield 46%) was obtained.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5750-76-5, 2,4,5-Trichloropyrimidine.
Reference:
Patent; Shandong Xuanzhu Pharma Co., Ltd.; Wu, Yongqian; (21 pag.)CN106146525; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia