Electric Literature of 26032-72-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.26032-72-4, name is 2,4-Dichloro-6-phenylpyrimidine, molecular formula is C10H6Cl2N2, molecular weight is 225.074, as common compound, the synthetic route is as follows.
Compound 1 was synthesized by the process of Reaction 1-3. 1.4 g of Compound D, 0.5 g of Compound E, 0.26 g of Pd(PPh3)4, and 0.92 g of K2CO3 were added to a 300 mL three neck flask under an argon atmosphere, followed by heating and refluxing in a mixed solvent of 100 mL toluene, 5 mL ethanol and 10 mL distilled water for about 15 hours. After cooling in the air, water was added, an organic layer was separated, and solvents were removed. The crude product thus obtained was separated by silica gel chromatography (using a mixed solvent of toluene/hexane), and recrystallized using hexane to obtain 0.61 g (yield 50%) of a target product as a white solid. The molecular weight of the target product measured by FAB-MS was 550. From the results, the target product was identified as Compound 1
Statistics shows that 26032-72-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-6-phenylpyrimidine.
Reference:
Patent; Samsung Display Co., Ltd.; Miyazaki, Yuuki; (92 pag.)US2019/131534; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia