Related Products of 26452-81-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.26452-81-3, name is 4-Chloro-6-methoxypyrimidine, molecular formula is C5H5ClN2O, molecular weight is 144.56, as common compound, the synthetic route is as follows.
A RBF containing 4-chloro-6-methoxypyrimidine (3.13 g, 21.62 mmol), 4-chloro-2- (tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (7.31 g, 21.62 mmol), Na2CCb (2.29 g, 21.62 mmol), DME (86 ml), EtOH (10.81 ml) and water (10.81 ml) was equipped with a condenser. The mixture was purged with Ar for several min then Pd(dppf)Cl2-CH2Cl2 adduct (1.77 g, 2.16 mmol) was added. The reaction was heated at 90 °C for 5 h. The reaction was cooled to rt, diluted with water and extracted with EtOAc. The organic layer was washed with brine, concentrated and purified by normal phase chromatography to give 4-chloro-2-(6-methoxypyrimidin-4-yl)aniline (2.86 g, 56.1 percent yield) as yellow solid. MS (ESI) m/z: 236.0 (M+H)+. NMR (500MHz, CDCh) delta 8.78 (d, J=l .1 Hz, IH), 7.49 (d,J=2.5 Hz, IH), 7.15 (dd, J=8.8, 2.5 Hz, IH), 6.99 (d, J=l . l Hz, IH), 6.67 (d, J=8.8 Hz, IH), 5.89 (br. s., 2H), 4.03 (s, 3H).
Statistics shows that 26452-81-3 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-6-methoxypyrimidine.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHU, Yeheng; DILGER, Andrew K.; EWING, William R.; ORWAT, Michael J.; PINTO, Donald J.P.; (156 pag.)WO2017/19821; (2017); A1;,
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