Synthetic Route of 347418-42-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 347418-42-2 as follows.
Step 1 To a solution of A16 (25 mg, 0.056 mmol) and 4-chloro-5-fluoropyrimidine (15 mg, 0.11 mmol) in DMSO (0.5 mL) was added CS2CO3 (37 mg, 0.11 mmol) and the mixture was stirred at 15C for 35 mins. The mixture was quenched with water (15 mL) and extracted with EtOAc (4 x 25 mL). The combined organic extracts were washed with brine (10 mL), dried over Na2S04, filtered and concentrated to provide CI as brown oil which was used in the next step without further purification. MS for CI m/e = 540.2 (M+l).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,347418-42-2, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn, P.; CUMMING, Jared, N.; DAI, Xing; (84 pag.)WO2017/139210; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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