Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62968-37-0, name is 4-(2-Chloropyrimidin-4-yl)morpholine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H10ClN3O
General procedure: To a solution of 32 were added 2-chloropyrimidine intermediate (3a-3e, 3g) (1 equiv) and catalytic amount of 1N HCl in AcOH. The reaction mixture and a magnetic bar were sealed in the reaction vessel of an Anton paar monowave 300 and irradiated for 2 h at 160 C. The reaction mixture was concentrated in vacuo and then diluted with H2O or saturated aqueous NaHCO3. The aqueous layer was extracted with EtOAc, and the combined organic layers were dried over MgSO4 and then concentrated in vacuo. The residue was purified by flash column chromatography on silica gel.
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Reference:
Article; Jo, Jeyun; Kim, Sou Hyun; Kim, Heegyu; Jeong, Myeonggyo; Kwak, Jae-Hwan; Taek Han, Young; Jeong, Jee-Yeong; Jung, Young-Suk; Yun, Hwayoung; Bioorganic and Medicinal Chemistry Letters; vol. 29; 1; (2019); p. 62 – 65;,
Pyrimidine | C4H4N2 – PubChem,
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