Reference of 72411-89-3, Adding some certain compound to certain chemical reactions, such as: 72411-89-3, name is 4-Methoxypyrimidine-5-carboxylic acid,molecular formula is C6H6N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72411-89-3.
Step A: Preparation of N,4-dimethoxy-N-methylpyrimidine-5-carboxamide. [00254] In a 500 mL single-neck flask equipped with a stir bar, 4-methoxypyrimidine-5- carboxylic acid (8.0 g, 33.2 mmol) and N,0-dimethylhydroxylamine hydrochloride (4.30 g, 43.2 mmol) were stirred in DCM (166 ml). DMAP (6.15 g, 49.8 mmol) and EDC hydrochloride (7.72 g, 39.9 mmol) were added. The mixture was stirred at 18 °C for 64 h, then silica (-50 g) was added to the reaction mixture. The yellow suspension was concentrated then loaded onto silica (-100 g). Chromatographed through a silica column (80 g) using EtOAc. The product fractions were concentrated to provide 2.4 g (36percent) of the title compound a colorless oil which was used without further purification. 1H NMR (400 MHz, CDC13) delta 8.81 (s, 1H), 8.48 (s, 1H), 4.05 (d, J = 0.7 Hz, 3H), 3.55 (s, 3H), 3.35 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72411-89-3, 4-Methoxypyrimidine-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DOW AGROSCIENCES LLC; LOSO, Michael R.; GUSTAFSON, Gary D.; KUBOTA, Asako; YAP, Maurice C.; BUCHAN, Zachary A.; STEWARD, Kimberly M.; SULLENBERGER, Michael T.; HOEKSTRA, William J.; YATES, Christopher M.; WO2015/160665; (2015); A1;,
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