Electric Literature of 3438-46-8, Adding some certain compound to certain chemical reactions, such as: 3438-46-8, name is 4-Methylpyrimidine,molecular formula is C5H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3438-46-8.
To a solution of 4-methylpyrimidine (543mg, 5.8mmol) in THF (30ml_) was added NaHMDS (1 M in THF, 12ml_, 12mmol) slowly at rt. The reaction mixture was stirred at rt for 30 min and a solution of ethyl 2,3-dihydrobenzo[b][1 ,4]dioxine-6-carboxylate (1 g, 4.8mmol) in THF (5ml_) was added slowly at rt. The reaction mixture was stirred at rt for 2 h. The TLC showed the reaction to be complete. The reaction mixture was poured into saturated aq NH4CI (50ml_) and extracted with EtOAc (3x50ml_). The organics were washed with brine (100ml_), dried (Na2S04), filtered and concentrated under reduced pressure. The crude residue was enriched up to 80% purity by trituration with pentane (25ml_), filtered and dried under reduced pressure to afford 1-(2,3-dihydrobenzo[b][1 ,4]dioxin-6-yl)-2-(pyrimidin-4-yl)ethan-1-one as a yellow solid. Yield: 1 g (81 %). MS (ESI+) for CHNOS m/z 257.18 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3438-46-8, 4-Methylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DISCUVA LTD.; MEO, Paul; KHAN, Nawaz; CHARRIER, Cedric; (252 pag.)WO2019/86890; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia