Synthetic Route of 66522-06-3, Adding some certain compound to certain chemical reactions, such as: 66522-06-3, name is 4-(tert-Butyl)-2-chloropyrimidine,molecular formula is C8H11ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 66522-06-3.
A mixture of 4-tert-butyl-2-chloropyrimidine (1.1 g, 6.4 mmol), 33% methylamine in ethanol (1 mL) in ethanol (4 mL) was placed in a sealed tube and heated to 60 C. for 3 h. The mixture was concentrated and the solid dissolved in chloroform. The organic layer was washed with water, dried over sodium sulfate, concentrated and chromatographed on silica gel with 30% EtOAc/Hexane. MS m/z 165 (MH)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 66522-06-3, 4-(tert-Butyl)-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Andersen, Denise Lyn; Chang, Catherine H.; Falsey, James R.; Frohn, Michael J.; Hong, Fang-Tsao; Liao, Hongyu; Liu, Longbin; Lopez, Patricia; Retz, Daniel Martin; Rishton, Gilbert M.; Rzasa, Robert M.; Siegmund, Aaron; Tadesse, Seifu; Tamayo, Nuria; Tegley, Christopher M.; US2006/69110; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia