In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10244-24-3, name is 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine, the common compound, a new synthetic route is introduced below. Quality Control of 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine
The 4,4 ‘ – (6-chloro-pyrimidine -2,4-diyl) two morpholine (5.0g, 17 . 6mmol), pinacone esterjoint boric acid (5.8g, 22 . 8mmol) and potassium acetate (2.59g, 26 . 4mmol) into acetonitrile (100 ml) in, under the protection of nitrogen by adding three ring hexyl phosphine (395 mg, 1 . 4mmol) and three (dibenzalacetone) palladium II (645 mg, 0 . 7mmol), the temperature is increased to 84 C reaction 3 hours, to take advantage of heat filtering, the filtrate after turns on lathe does adding toluene (30 ml) and petroleum ether (100 ml), stirring, precipitate, filtered, the filter cake is washed with petroleum ether washing, to obtain the title compound (3.8g, yield 57.4%).
The synthetic route of 10244-24-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Xuanzhu Oharma Co., Ltd.; Wu, Yongjian; (47 pag.)CN105541792; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia