4595-59-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4595-59-9, name is 5-Bromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: K3PO4 (531 mg, 2.5 mmol) was added to a solution of 5-bromopyrimidine (1) (159 mg, 1.0 mmol), 2-thienylboronic acid(2) [3-thienylboronic acid (3), benzo[b]thien-2-ylboronic acid (4) orbenzo[b]thien-3-ylboronic acid (5)] (1.5 mmol) and trans-bis(dicyclohexylamine)palladium(II) acetate (29 mg, 0.05 mmol) in EtOH(10 mL). The resulting suspension was stirred at ambient temperaturefor 24 h. EtOH was evaporated under reduced pressure andthe residue was suspended in CH2Cl2 (20 mL) and filtered frominorganic salts. After that solvent was distilled off under reducedpressure, and the residue was purified by flash column chromatographyon silica gel (hexane/ethyl acetate, 1:3) to afford thedesired cross-coupling products (6, 7, 8 or 9).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4595-59-9, 5-Bromopyrimidine.
Reference:
Article; Verbitskiy, Egor V.; Cheprakova, Ekaterina M.; Slepukhin, Pavel A.; Kravchenko, Marionella A.; Skornyakov, Sergey N.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.; European Journal of Medicinal Chemistry; vol. 97; (2015); p. 225 – 234;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia